Pyruvate Oxidation and Kreb's Cycle

Takes place in the mitochondrial matrix
C= carbon


PYRUVATE OXIDATION
STEP 1:  pyruvate (3 C) -->acetyl CoA (2 C)
What's happening? 
1 carbon is cleaved -->becomes CO2, and NAD+-->NADH + H+

KREB'S CYCLE
STEP 2: acetyl CoA (2 C) + oxaloacetate (4 C)--> citrate 

STEP 3: citrate (6 C)-->isocitrate (6 C)
What's happening?
Isomerization


STEP 4: isocitrate (6 C)--> alpha-ketoglutarate (5 C)
What's happening?
Decarboxylation--> CO2 is produced, and NAD+-->NADH + H+


STEP 5: alpha-ketoglutarate (5 C)-->succinyl CoA (4 C)
What's happening?
CoA is used and dumped 
Decarboxylation--> CO2 is produced, and NAD+--> NADH + H+


STEP 6: succinyl CoA (4 C)--> succinate (4 C)
What's happening?
CoA is used and dumped
Substrate-level Phosphorylation--> ADP + Pi--> ATP

 STEP 7: succinate (4 C)-->fumarate (4 C)
What's happening?
FAD+-->FADH2


STEP 8: fumarate (4 C)--> malate (4 C)
What's happening?
H2O is added 


STEP 9: malate (4 C)--> oxaloacetate (4 C)
What's happening?
NAD+ --> NADH + H+


CONCLUSION
PYRUVATE OXIDATION
2 NADH
2 CO2

KREB'S CYCLE
2 FADH2
2 ATP
6 NADH
4 CO2